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Walkthrough 21 of 29 · Desktop
Embryology: PGT-M readiness, a media recall and warming authorization
A missing family sample, a culture-media recall and an embryo that doesn't survive warming, each traced to the exact embryo, case and decision.
- Length
- 0:37
- Chapters
- 7
- Shown on
- Desktop embryology and genetics workspace
- Later phase
- Prototype walkthrough · Fictional patient data
Embryology: PGT-M readiness, a media recall and warming authorization, muted recording of the design prototype. Fictional patient data.
Chapter 1 of 7
Chapter 1 of 7: PGT-M: the missing family sample
Recorded from an interactive design prototype. Every patient, clinician and clinic is fictional, EMR screens are modeled reconstructions, and nothing shown is a live connection to any clinic or vendor system.
Clinical & operational context
The situation on screen, why it matters, and where OvaFlow stops.
Three lab situations, each traced precisely. A missing family sample holds up PGT-M preparation; a culture-media lot notice opens an investigation with a named reviewer for every affected case; and warming is authorized for one exact embryo. If that embryo doesn't survive, warming another needs a new authorization.
What clinical situation this depicts
Inside the embryology laboratory, coordination failures carry irreversible consequences: starting stimulation for a monogenic preimplantation genetic testing (PGT-M) cycle before the reference lab has received the family linkage swab and finished probe validation; losing track of biopsy lineage when an embryo undergoes a second trophectoderm biopsy; failing to identify which embryos touched a recalled culture-media lot; or warming an embryo on transfer morning when a day-of clinical deferral was just called from the ultrasound room.
This 7-chapter embryology walkthrough traces those high-consequence laboratory checkpoints: holding PGT-M cycle start when a required family linkage sample is missing, preserving parent-to-biopsy lineage across a re-biopsy event, handling a cohort with zero usable blastocysts with immediate clinician-to-patient call coordination, tracing every dish and embryo exposed to a recalled culture-media lot, verifying the exact single authorized embryo before warming, halting warming when a day-of clinical deferral occurs, and coordinating the immediate backup/clinician protocol if an embryo does not survive warming.
Step-by-step workflow
Embryology readiness gates: PGT-M linkage, lot traceability, and warming authorization
Step 1Pre-cycle check
OvaFlow safeguard
Holds start until family linkage sample & probe clear
Step 2Biopsy & lot log
Embryology lab
Tracks re-biopsy lineage and culture-media lot exposure
Step 3Transfer morning
OvaFlow safeguard
Verifies exact authorized embryo ID and active consent
Step 4Lab-to-clinic link
Embryology lab
Halts on day-of deferral or escalates non-survival immediately
How OvaFlow connects laboratory readiness, reagent lot recall tracing, and transfer-morning warming gates to the clinical team.
Guardrail: No embryo warming proceeds without matching consent, clinician authorization, and cleared day-of clinical readiness.
What OvaFlow coordinates in this recording
- Holds PGT-M cycle start until family linkage samples and reference-lab probe readiness are confirmed.
- Maintains parent-embryo-to-biopsy lineage across repeat biopsies and traces affected records during a culture-media lot recall.
- Verifies exact embryo authorization before warming and halts immediately on a day-of clinical deferral.
What stays with clinicians & the clinic's own systems
- Never grades embryos, selects which embryo to transfer, or interprets PGT ploidy/monogenic results.
- Never sends an automated '0 blastocysts' portal message without a clinician speaking to the patient first.
- Never authorizes warming a backup embryo without clinician and patient consent verification.
Terms in this walkthrough
Full glossary- PGT-MIVF termGenetic testing for a specific inherited condition. It often needs family samples and lab preparation before the cycle starts.
- Embryo biopsyIVF termRemoving a few cells from an embryo for genetic testing. One embryo can have more than one biopsy record.
Show 3 more glossary terms in this walkthrough
- BlastocystIVF termAn embryo at about five to seven days of development.
- Lot recallIVF termA manufacturer notice that a batch of lab supplies, such as culture media, may be affected and needs to be traced.
- WarmingIVF termBringing vitrified (flash-frozen) embryos or eggs out of storage so they can be used. Which ones are warmed is a specific, authorized decision.
What to watch for
What could go wrong, and what you'll see instead.
Three lab situations, each traced precisely. A missing family sample holds up PGT-M preparation; a culture-media lot notice opens an investigation with a named reviewer for every affected case; and warming is authorized for one exact embryo. If that embryo doesn't survive, warming another needs a new authorization.
The problems it is designed around
- A missing family sample or a change of genetics lab leaving PGT-M unready mid-cycle.
- A culture-media lot recall needing days of paper-binder searches.
- An automatic second-embryo warming after the first doesn't survive, without a new decision.
What you'll see in the recording
- The PGT-M critical path
- Lineage across two biopsies
- A media lot recall with a reviewer for every case
- Exact-embryo warming, and a new decision if it doesn't survive
Chapter-by-chapter guide
Every chapter in this 0:37 walkthrough (7 chapters)
Follow the exact timestamps, UI status changes, and coordination safeguards as the recording plays.
PGT-M: the missing family sample
What to watch for: Before stimulation begins for a PGT-M case, OvaFlow flags a missing family linkage sample so the cycle is not started prematurely.
Boundary rule: PGT-M probe setup is verified before gonadotropins start, preventing an un-testable biopsy cohort.
On-screen narration: A missing family sample is holding up the PGT-M probe build. The genetics lab confirms assay readiness for the agreed case. Switching reference labs requires a fresh commitment from the new lab. An accepted backup sperm source is confirmed before retrieval day.
Show chapters 2–7 (6 more chapters with timestamps & boundary notes)
Lineage across two biopsies
What to watch for: When an inconclusive blastocyst undergoes a second biopsy, both biopsy sample IDs stay tied to the same parent embryo record.
Boundary rule: Lineage visibility prevents sample mix-ups across initial and repeat PGT reports.
On-screen narration: Two biopsy records on one embryo keep their own lineage.
When there are no usable blastocysts
What to watch for: If no blastocysts reach biopsy/freeze criteria, an urgent clinician-owned call task opens before any routine portal digest can fire.
Boundary rule: Difficult embryology news is delivered by a clinician first, never by an automated notification.
On-screen narration: No usable blastocysts: the lab result is carried to the clinical plan. Clinical and patient follow-up are aligned with the lab outcome.
A culture-media lot recall
What to watch for: Entering a recalled culture-media lot number lists every affected cycle, dish, and stored embryo for laboratory and clinical review.
Boundary rule: Lot exposure tracing links laboratory records to the clinical disclosure workflow.
On-screen narration: A manufacturer notice for a culture-media lot opens an investigation. Three dish-use records need their lot details checked. Bench records are attached to fill in the missing lot entries. A named lab director or clinician reviewer is assigned to every exposed case. The investigation closes with a complete record across every affected case.
Warming exactly the authorized embryo
What to watch for: On warming morning, the gate checks the exact embryo identifier, single-embryo authorization, and signed episode consent.
Boundary rule: Warming requires exact agreement between the signed transfer order, consent, and cane/goblet location.
On-screen narration: The exact embryo and its warming authorization are confirmed before warming. The completed transfer is reconciled against the lab's own record.
A day-of deferral
What to watch for: When the clinic calls a day-of medical deferral (for example, fluid in the endometrial cavity), the warming gate locks immediately.
Boundary rule: Real-time clinical deferral signals stop warming before the straw leaves liquid nitrogen.
On-screen narration: The recipient's medical deferral on the day of transfer opens a different path. A refreeze or disposition owner and clinical follow-up are assigned.
If the embryo doesn't survive
What to watch for: If an embryo does not survive warming, the embryologist triggers an immediate clinician handoff before any backup warming occurs.
Boundary rule: Backup embryo warming requires explicit clinician and patient authorization under the signed consent.
On-screen narration: Stepping back to the safeguard for an embryo that doesn't survive warming. Back to the warming authorization. The warmed embryo's non-survival is recorded in the lab's own record. Warming any backup embryo requires a new, explicit authorization.
OvaFlow never makes the clinical call in these recordings. Physicians sign, the person taking a handoff accepts it, and the lab keeps its own holds. The companion tracks, checks and stops; staff decide.
In this walkthrough
The people on screen
Every patient, family member, clinician and clinic in these stories is fictional. Names, times and screens come from prototype walkthroughs, not from real care.
- Lab directorCloses the investigation
- Senior embryologistAuthorizes and records warming
- Genetics coordinatorTracks PGT-M readiness
- REI physicianMakes the clinical decisions
Systems often found around this workflow
Show 4 systems around this workflow
Systems a clinic running this workflow often uses. They do not appear in this recording.
Electronic witnessing (RI Witness) & PGT genetics
Electronic witnessing & embryology lab technology
PGT & reproductive genetics lab
PGT & embryo genomics lab
Third-party names and logos are trademarks of their respective owners, shown to illustrate systems commonly used in IVF clinics. No affiliation, endorsement or live integration is implied. nAbleIVF, eIVF and Artisan appear as modeled workflow examples.
Where this appears
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This recording is part of these pages. Each one explains the step in more depth.
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Roles
Surfaces
Stories
Guided tours
Questions & answers
Common questions about this walkthrough
What clinicians, coordinators, practice leaders, and patients ask when reviewing Walkthrough 21.
Why does OvaFlow check PGT-M family linkage samples before ovarian stimulation starts?
Monogenic PGT-M often requires DNA samples from parents or relatives so the reference genetics lab can build and validate the custom test workup. Catching a missing family swab before Day 1 avoids retrieving oocytes before the test is ready.
What happens if a cohort has zero usable blastocysts on Day 6 or Day 7?
OvaFlow holds automated portal digests and assigns a high-priority callback to the reproductive endocrinologist so the patient hears from her physician directly.
Show 1 more walkthrough questions
How does the day-of deferral stop protect the embryo?
If the morning ultrasound or nursing check identifies a reason to postpone transfer, flagging the deferral immediately turns the embryology warming gate red before warming begins.
Related
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Show 2 more related walkthroughs
eIVF: note save, financial blocker, e‑prescribing handoff, PGT stop
A note isn't done until it's saved, a cycle doesn't start with prior authorization unresolved, dose changes go to eIVF's own e-prescribing, and a PGT label mismatch stops the review.
Lab & pharmacy core: witnessing, prior auth, delivery and readiness
From duplicate barcodes to cold-chain delivery and the patient's own “received”, every handoff to the clinic's own system has an owner and a confirmation.
Next step
Walk through it with your own team.
We'll replay this flow against your roles and handoffs, using fictional records. Please don't send patient data.